The stats are for COVID-associated hospitalizations, which may include people for whom COVID-19 was not the primary reason for admission. Nat Commun 14, 894 (2023). N. Engl. 386, 15321546 (2022). Third, because immunocompromise status is not always known, it is not possible to distinguish between booster and additional doses; this could have influenced observed rates. Delahoy MJ, Whitaker M, OHalloran A, et al. The average age of decedents was 83.3 years. A and B, Markers indicate estimates, with vertical lines indicating 95% CIs. In-hospital death status was missing in 1.4% (weighted) of hospitalizations; these hospitalizations are otherwise included elsewhere in the analysis. We monitored the seroprevalence of SARS-CoV-2 nucleocapsid (anti-N) and spike protein (anti-S) antibodies in blood donors across Canada from September 2021 to June 2022 in 202,123 . J. Data were available for researchers who meet the criteria for access to Kaiser Permanente Northern California confidential data. Age-adjusted rates were calculated by dividing the number of hospitalized COVID-19 patients by population estimates for race/ethnicity, and vaccination status in the catchment area. Our findings that receipt of at least two doses of COVID-19 vaccine during pregnancy was effective at protecting infants during the Delta period are similar to those reported in a recent Norwegian study showing that mRNA COVID-19 vaccination during pregnancy was associated with a 71% decreased risk of testing positive for SARS-CoV-2 in infants during their first 4 months of life during the Delta period17. Effectiveness of Covid-19 vaccines in ambulatory and inpatient care settings. Despite several studies showing that vaccination during pregnancy is safe for pregnant people24,25,26,27,28, vaccine uptake has been suboptimal in this group29. Additional COVID-NET methods for determining vaccination status have been described previously. * Overall rates are unadjusted; rates presented by racial and ethnic group are age-adjusted. In this analysis, vaccine effectiveness was evaluated as 1 minus the odds ratio. Two recent papers claim there are no differences between surgical masks and respirators for preventing the spread of respiratory diseases like COVID-19 and flu, but the articles are deeply flawed. The cohort analyses may be biased toward the null if some infected infants were misclassified as uninfected due to the absence of a SARS-CoV-2 test result in the medical record. The final study population included 30311 (48.8%) infants who were KPNC members at least 2 months after birth. Pre-Omicron versions of Covid, in. Jackson, M. L. & Nelson, J. C. The test-negative design for estimating influenza vaccine effectiveness. Abbreviation: COVID-NET = COVID-19Associated Hospitalization Surveillance Network. Thus, this design better adjusts for healthcare-seeking behavior31,32, but it may also introduce other biases including selection bias33. From Jan 1 to Mar 16, 2022, when Omicron was predominant, 4,781 (0.02%) of 19,473,570 booster recipients died of COVID-19, and 58,020 (0.3%) died of other causes. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. The remaining authors declare no competing interests. N. Engl. Dagan, N. et al. In the first study, a team led by US Centers for Disease Control and Prevention (CDC) researchers analyzed data on 192,509 hospitalizations from more than 250 hospitals in 13 states participating in the COVID-19Associated Hospitalization Surveillance Network from Jan 1, 2021, to Apr 30, 2022. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. The TND is designed to better control for bias related to health care-seeking behavior31,32. TN, NMF, SFlax, SFunk, SA, SB, and ST did the formal analysis. MMWR Morb Mortal Wkly Rep 2022;71:1328. We take your privacy seriously. Female sex was a protective factor (HR, 0.52), while residence in a nursing home or low-income area was a risk factor. mmwrq@cdc.gov. Google Scholar. Wkly Rep. 71, 352358 (2022). Gynecol. Monthly COVID-19 hospitalization rates were 3.5 to 17.7 times higher in unvaccinated patients than in their vaccinated counterparts, regardless of whether they had received a booster. In the present study, the mothers of only 32% of infants in the cohort received at least 2 doses during pregnancy. However, we have no reason to expect a strong association between the absence of NHS number and SARS-CoV-2 variant. J., Fireman. However, these Omicron impacts have been mostly observed in countries with high vaccination rates in the Region: the comparatively lower rate of hospitalizations and deaths so far is in large part thanks to vaccination, particularly of vulnerable groups. Slider with three articles shown per slide. Arthur Reingold, Jeremy Roland, Ashley Coates, California Emerging Infections Program, Oakland, California; Breanna Kawasaki, Rachel Herlihy, Isaac Armistead, Madelyn Lensing, Jordan Surgnier, Sarah McLafferty, Colorado Department of Public Health & Environment; Ann Basting, Tessa Carter, Maria Correa, Daewi Kim, Carol Lyons, Hazhia Sorosindi, Connecticut Emerging Infections Program, Yale School of Public Health, New Haven, Connecticut; Emily Fawcett, Katelyn Ward, Jana Manning, Asmith Joseph, Allison Roebling, Chandler Surell, Stephanie Lehman, Taylor Eisenstein, Suzanne Segler, Grayson Kallas, Marina Bruck, Rayna Ceaser, Annabel Patterson, Sabrina Hendrick, Johanna Hernandez, Hope Wilson, School of Medicine, Emory University, Georgia Emerging Infections Program, Georgia Department of Public Health, Veterans Affairs Medical Center, Foundation for Atlanta Veterans Education and Research, Atlanta, Georgia; Jim Collins, Shannon Johnson, Justin Henderson, Sue Kim, Alexander Kohrman, Lauren Leegwater, Val Tellez Nunez, Sierra Peguies-Khan, Michigan Department of Health and Human Services; Kayla Bilski, Kristen Ehresmann, Richard Danila, Jake Garfin, Grace Hernandez, Kieu My Phi, Ruth Lynfield, Sara Vetter, Xiong Wang, Minnesota Department of Health; Daniel M. Sosin, Susan L. Ropp, Sunshine Martinez, Jasmyn Sanchez, Cory Cline, Melissa Judson, Florent Nkouaga, Mark Montoya, New Mexico Department of Health; Sarah Lathrop, Kathy M. Angeles, Yadira Salazar-Sanchez, Sarah A. Khanlian, Nancy Eisenberg, Dominic Rudin, Sarah Shrum Davis, Mayvilynne Poblete, Emily B. Hancock, Francesca Pacheco, New Mexico Emerging Infections Program; Yassir Talha, Celina Chavez, Jennifer Akpo, Alesia Reed, Murtada Khalifa, CDC Foundation, New Mexico Department of Health; Suzanne McGuire, Kerianne Engesser, Nancy Spina, Adam Rowe, New York State Department of Health; Sophrena Bushey, Virginia Cafferky, Maria Gaitan, Christine Long, Thomas Peer, Kevin Popham, University of Rochester School of Medicine and Dentistry, Rochester, New York; Julie Freshwater, Denise Ingabire-Smith, Ann Salvator, Rebekah Sutter, Ohio Department of Health; Sam Hawkins, Public Health Division, Oregon Health Authority; Tiffanie Markus, Katie Dyer, Karen Leib, Terri McMinn, Danielle Ndi, Gail Hughett, Emmanuel Sackey, Kathy Billings, Anise Elie, Manideepthi Pemmaraju, Vanderbilt University Medical Center, Nashville, Tennessee; Amanda Carter, Andrea George, Andrew Haraghey, Ashley Swain, Caitlin Shaw, Laine McCullough, Mary Hill, Ryan Chatelain, Salt Lake County Health Department, Salt Lake City, Utah; Alvin Shultz, Robert W. Pinner, Rainy Henry, Sonja Mali Nti-Berko, CDC; Elizabeth Daly, Council of State and Territorial Epidemiologists. Kim, L. et al. Gordon, N. & Lin, T. The Kaiser Permanente Northern California adult member health survey. Risk factors for severe COVID-19 in children. Omicron is super infectious, and about 20% of people in the United States over the age of 5 as well as all children under 5 remain unvaccinated. 384, 21872201 (2021). These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. Just 28% of children in the age group - around 8 million . Relative to the Delta-predominant period, a larger proportion of hospitalized Black adults were unvaccinated. Users are referred to the electronic PDF version (https://www.cdc.gov/mmwr) The group raised concerns about a small number of Guillain-Barre syndrome cases in vaccine recipients and wanted more data, especially on efficacy in those at highest risk. Rates are calculated using the CDC National Center for Health Statistics vintage 2020 bridged-race postcensal population estimates for the counties included in surveillance. During the period of Omicron predominance, hospitalization rates increased most sharply among Black adults in the United States relative to all other racial and ethnic groups examined and reached the highest rate observed among all racial and ethnic groups since the beginning of the pandemic. Real-world data suggest lower COVID-19 vaccine effectiveness against Omicron variants11,12,13,14. Safety and efficacy of the BNT162b2 mRNA covid-19 vaccine. Data from the COVID-19Associated Hospitalization Surveillance Network (COVID-NET) were analyzed to compare COVID-19associated hospitalization rates among adults aged 18 years during B.1.617.2 (Delta; July 1December 18, 2021) and Omicron (December 19, 2021January 31, 2022) variant predominance, overall and by race/ethnicity and vaccination status. adjudicated chart reviews. Hospitalization rates and characteristics of children aged <18 years hospitalized with laboratory-confirmed COVID-19COVID-NET, 14 States, March 1-July 25, 2020. Children and COVID-19: state data report. Relative to unvaccinated hospitalized patients, hospitalized vaccinees were more likely to be older (median age, 70 vs 58 years) and to have at least three underlying conditions (77.8% vs 51.6%). A recent study found that the mean titer of maternally derived antibodies in infants of vaccinated mothers were higher at age 2 months compared with antibody titers at age 6 months23. In the meantime, to ensure continued support, we are displaying the site without styles Vaccine 40, 656665 (2022). Association of COVID-19 vaccination during pregnancy with incidence of SARS-CoV-2 infection in infants. There were only one hospitalized case among the children of vaccinated mothers and nine hospitalized cases among the children of unvaccinated mothers (Table1). Office of the Vice President for Research. Maternal SARS-CoV-2 vaccination and infant protection against SARS-CoV-2 during the first six months of life, https://doi.org/10.1038/s41467-023-36547-4. 387, 227236 (2022). Science brief: omicron (B.1.1.529) variant. Open 5, e2233273 (2022). To account for the correlation between infants with the same mother, we fit marginal Cox proportional hazards models using robust sandwich variance estimates. TN and NMF were responsible for visualisation. The prevalence of primary COVID-19 vaccination and of receipt of a booster dose were lower among Black adults compared with White adults. This analysis describes weekly hospitalization rates during Delta- and Omicron-predominant periods. Additional recommendations followed and data availability on booster-dose status varies by age because not all age groups were recommended by ACIP to receive booster doses at the same time. Abbreviations: COVID-NET = COVID-19Associated Hospitalization Surveillance Network; ICU=intensive care unit; IMV=invasive mechanical ventilation; LTCF=long-term care facility; NA = not applicable. Hospitalization rates during peak Omicron circulation (January 2022) among unvaccinated adults remained 12 times the rates among vaccinated adults who received booster or additional doses and four times the rates among adults who received a primary series, but no booster or additional dose. JAMA Intern. Christopher A. Taylor, PhD1; Michael Whitaker, MPH1; Onika Anglin, MPH1,2; Jennifer Milucky, MSPH1; Kadam Patel, MPH1,2; Huong Pham, MPH1; Shua J. Chai, MD3,4; Nisha B. Alden, MPH5; Kimberly Yousey-Hindes, MPH6; Evan J. Anderson, MD7,8,9; Kenzie Teno, MPH10; Libby Reeg, MPH11; Kathryn Como-Sabetti, MPH12; Molly Bleecker, MA13; Grant Barney, MPH14; Nancy M. Bennett, MD15; Laurie M. Billing, MPH16; Melissa Sutton, MD17; H. Keipp Talbot, MD18; Keegan McCaffrey19; Fiona P. Havers, MD1; COVID-NET Surveillance Team (View author affiliations). In supplemental analyses by trimester of vaccination, receipt of the second dose during the second and third trimesters reduced the risk of infants testing SARS-CoV-2 positive during the Delta dominant period by 91% (95% CI: 63, 98) and 85% (95% CI: 50, 96), respectively, during the first 2 months of life, by 59% (95% CI: 21, 79) and 67% (95% CI: 37, 83) during the first 4 months of life and by 64% (95% CI:31, 81) and 53% (95% CI: 24, 71) during the first 6 months of life. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Pediatr. Children currently account for about 18.5% of reported COVID-19 cases in the United States1. NEW YORK and MAINZ, GERMANY, March 1, 2023 Pfizer Inc. (NYSE: PFE) and BioNTech SE (Nasdaq: BNTX) today submitted an application to the U.S. Food and Drug Administration (FDA) for Emergency Use Authorization (EUA) of a booster (fourth) dose of the companies' Omicron BA.4/BA.5-adapted bivalent COVID-19 vaccine in children 6 months through 4 years of age (also referred to as under 5 years). https://doi.org/10.1038/s41467-023-36547-4, DOI: https://doi.org/10.1038/s41467-023-36547-4. Methods: This is a retrospective cohort study that was conducted in Israel's second-largest . Mountain lions, a bobcat, red foxes, black bears, and skunks represent the latest avian flu cases in mammals. Sect. The findings in this report are subject to at least four limitations. Without the vaccines many more people would likely be in hospital. All information these cookies collect is aggregated and therefore anonymous. Mothers were classified as either having had 2 doses or one dose of mRNA COVID-19 vaccines during pregnancy (and completed more than 14 days prior to delivery) or not having had any COVID-19 vaccines prior to delivery. The report shows people catching Omicron are: 31% to 45% less likely to go to A&E. 50% to 70% less likely to be admitted to hospital for treatment. These findings are consistent with estimates of booster effectiveness against symptomatic Omicron infection using healthcare ascertainment. IMV status was missing in 1.4% (weighted) of hospitalizations; these hospitalizations are otherwise included elsewhere in the analysis. COVID-19 hospitalization rates per 100,000 population by age and vaccination status, January 05 to February 01, 2023 Age group Age-specific rate per 100,000 among unvaccinated individuals Age-specific rate per 100,000 among those who received at least one booster dose Likelihood of unvaccinated individuals being hospitalized with Urban Health 83, 10411062 (2006). Data requests may be sent to Kaiser Permanente Division of Research: DOR.IRB.Submissions@kp.org. Adults with a positive result whose SARS-CoV-2 test date was 14 days after the first dose of a 2-dose series but <14 days after receipt of the second dose were considered partially vaccinated. J. Med. Rep. 71, 2630 (2022). pdf files, Omicron: fewer adverse outcomes come with new dangers, Statement on offensive historical content, Redistribute or republish the final article, Reuse portions or extracts from the article in other works.
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