Licorice. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Tell your doctor if this medication stops working well (for example, you have more frequent or worsening chest pain). Once- versus twice-daily administration of controlled-release isosorbide-5-mononitrate 60 mg in the treatment of stable angina pectoris. If it is within 2 hours of the next dose, skip the missed dose. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education. Accessed Sept. 7, 2022. Should I avoid certain foods while taking Isosorbide Mononitrate? [2] It is taken by mouth. US residents can call their local poison control center at 1-800-222-1222. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. sharing sensitive information, make sure youre on a federal Isosorbide mononitrate has an average rating of Your doctor may decide not to treat you with this medication or change some of the other medicines you take.AvanafilRiociguatSildenafilTadalafilVardenafil. Limit alcoholic beverages. If this worries you, talk to your doctor or pharmacist about other options. Talk to your provider if you notice your chest pain starts to get worse. Cao HY, Wu HD, Song ZK, Tang ML, Yang S, Liu Y, Qin L. Pan Afr Med J. MBBS, MS - General Surgery, mch neuro surgery. Accessed Sept. 7, 2022. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome. 2023 Lybrate, Inc. All rights reserved. Please note that only the generic name of each medication is listed below. There are no data on passage of isosorbide mononitrate in human milk, but some excretion seems likely. Isosorbide mononitrate (Monoket) works slowly to help prevent chest pain. It is not suitable to take to treat an angina attack - you should always carry with you a short-acting nitrate, such as glyceryl trinitrate (GTN), for if you get angina pain. Includes Isosorbide Mononitrate indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more. These relax smooth muscle within the blood vessels, widening them and making it easier for blood and oxygen to reach the heart Calcium antagonists (eg, diltiazem, nifedipine, nimodipine, verapamil). Real test is coronary angiography. Isosorbide mononitrate (Monoket) is available as both a immediate-release (IR, short-acting) and extended-release (ER, long-acting) tablet. 1996 Dec;3(12):802-806. doi: 10.1097/00045391-199612000-00003. Ginkgo. Never take more than the prescribed dose. health information, we will treat all of that information as protected health This does not necessarily mean no interactions exist. The tablet usually is taken two or three times daily. Natural Medicines. Review/update the Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Who should not take Isosorbide Mononitrate? Symptoms of overdose may include: slow heartbeat, vision changes, severe nausea/vomiting, sweating, cold/clammy skin, bluish fingers/toes/lips. Alcohol, including beer, wine, and spirits, does raise your blood pressure if its consumed in excess. People with kidney problems should be able to take the usual dose of isosorbide mononitrate (Monoket). Dehydration in Buspar, how severe and when it was recovered? The most common side-effect is headache. Your doctor will tell you which is the right dose for you, and this will also be printed on the label of the pack to remind you about what the doctor said to you. Let your doctor know immediately if you continue to experience these symptoms or if they worsen over time. McGraw Hill; 2022. https://accessmedicine.mhmedical.com/search. May also be prescribed off label for Esophageal Spasm. All Rights Reserved. This medication performs a vasodilatory function and is therefore used as a treatment for high blood pressure. Do not store in the bathroom. Clin Res Cardiol. View more, Nitroglycerin dilates veins, relieving chest pain and lowering blood pressure. Synthroid (levothyroxine) Tylenol (acetaminophen) Vitamin B12 (cyanocobalamin) Vitamin C (ascorbic acid) Vitamin D3 (cholecalciferol) Isosorbide mononitrate disease interactions There are 7 disease interactions with isosorbide mononitrate which include: AMI anemia hemodialysis hypotension intracranial pressure hypertrophic cardiomyopathy glaucoma Stopping isosorbide mononitrate (Monoket) suddenly can cause you to have a worsening of your chest pain. Consult your doctor before breast-feeding. The extended-release capsule usually is taken once daily. Do infrared saunas have any health benefits? Coenzyme Q-10 Natural Medicines. Pricing based on most commonly-filled versions: 180 tablets of isosorbide mononitrate 10mg. Prescription and OTC Aspirin relieves pain and inflammation and helps to thin the blood. 41% of reviewers reported a positive effect, while 50% reported a negative effect. prevention of anginal chest pain associated with coronary artery disease, prevent bleeding varicose vein in the esophagus. This list covers only some interactions. Herbal supplements can strongly affect the body. Contact your provider right away if you feel as if you are going to pass out and are experiencing an irregular heartbeat, nausea, vomiting, changes in vision, more sweating, or cold and clammy skin. tell your doctor if you are taking or have recently taken riociguat (Adempas) or a phosphodiesterase inhibitor (PDE-5) such as avanafil (Stendra), sildenafil (Revatio, Viagra), tadalafil (Adcirca, Cialis), and vardenafil (Levitra, Staxyn). Natural Medicines. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Mayo Clinic does not endorse companies or products. Of the total drug interactions, If you forget to take a dose, take it as soon as you remember. May also be prescribed off label for Esophageal Spasm. When used regularly on a long-term basis, this helps prevent angina attacks from occurring. It is also important information to carry with you in case of emergencies. tell your doctor and pharmacist if you are allergic to isosorbide; nitroglycerin tablets, patches, or ointment; any other medications, or any of the ingredients in isosorbide tablets, extended-release tablets, or extended-release capsules. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. This content does not have an Arabic version. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Isosorbide dinitrate (Isordil) is available as both a short-acting tablet and long-acting capsule. 2021 May 11;39:28. doi: 10.11604/pamj.2021.39.28.22180. This is called tolerance, and it cannot be fixed by raising the dose of the medication. you should know that isosorbide may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position, or at any time, especially if you have been drinking alcoholic beverages. It is not suitable to take to treat an angina attack - you should always carry with you a short-acting nitrate, such as glyceryl trinitrate (GTN), for if you get angina pain. Trapidil is as effective as isosorbide-dinitrate for treating stable angina pectoris: a multinational, multicenter, double-blind, randomized study. (2) One in 3 patients never experienced headache from the given dosages. Many herbal supplements can interact with prescription drugs. All rights reserved. amlodipine, lisinopril, aspirin, metoprolol, furosemide, carvedilol, propranolol, spironolactone, atenolol, diltiazem. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. Yet many herbal supplements may interact with heart disease medicines. Liperoti R, et al. Yet significantly fewer patients had headache on low dosage than on high dosage (45 vs 57, P < 0.02). 2006 Apr;95(4):217-23. doi: 10.1007/s00392-006-0367-x. Some products have ingredients that could worsen your heart failure. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Then, there was a two-week placebo washout, after which the alternative treatment was given. Imdur (isosorbide mononitrate) Extended Release and Isordil (isosorbide dinitrate) are vasodilators indicated for the prevention of angina pectoris due to coronary artery disease.. Side effects of Imdur and Isordil that are similar include headache and dizziness.. Side effects of Isordil that are different from Imdur include weakness and skin changes such as redness, tingling, or warmth. and transmitted securely. We study millions of patients and 5,000 more each day. Bookshelf Some don't work well with prescription medicines. What are the interactions of Isosorbide Mononitrate ? . Follow directions about how much medicine to take. I strongly feel that there is coronary ischemia. You may report side effects to Health Canada at 1-866-234-2345. This site complies with the HONcode standard for trustworthy health information: verify here. Herbal supplements are natural, so they must be safe, right? Alcohol will increase the risk of you experiencing side-effects such as feeling dizzy and light-headed. Alternative drugs to the conditions Isosorbide mononitrate treats: Angina High blood pressure Stable angina Chest pain Heart disease Heart attack Angina unstable Heart disease congenital Coronary heart disease Heart failure Pulse Heart rate irregular Coronary artery spasm Angioplasty Isosorbide mononitrate vs. Amlodipine besylate, Isosorbide mononitrate vs. Bisoprolol fumarate, Isosorbide mononitrate vs. Diltiazem hydrochloride, Isosorbide mononitrate vs. Isosorbide dinitrate, Isosorbide mononitrate vs. Metoprolol succinate, Isosorbide mononitrate vs. Metoprolol tartrate, Isosorbide mononitrate vs. Nitrolingual pumpspray, Isosorbide mononitrate and Aspirin (7,880 reports), Isosorbide mononitrate and Furosemide (6,020 reports), Isosorbide mononitrate and Amlodipine (3,554 reports), Isosorbide mononitrate and Simvastatin (3,508 reports), Isosorbide mononitrate and Omeprazole (3,422 reports), Isosorbide mononitrate and Lisinopril (3,099 reports), Isosorbide mononitrate and Metformin (2,822 reports), Isosorbide mononitrate and Carvedilol (2,589 reports), Isosorbide mononitrate and Clopidogrel (2,524 reports), Isosorbide mononitrate and Acetylsalicylic acid (2,355 reports). Registered in England and Wales. Diabetes treatment: Can cinnamon lower blood sugar? Consult your pharmacist or local waste disposal company. Herbal supplements can interact with medicines used to treat heart and blood vessel problems, such as high blood pressure and heart failure. 7 disease interactions. Bethesda, MD 20894, Web Policies Bauer B (expert opinion). View interaction reports for isosorbide mononitrate and the medicines listed below. Cleophas TJ, Niemeyer MG, Zwinderman AH, van der Wall EE. While both isosorbide mononitrate (Monoket) and nitroglycerin (Nitrostat) are both nitrate vasodilators, they are not the same medication. This medicine is available only with your doctor's . Saw palmetto. Commonly reported side effects include: See also: isosorbide mononitrate side effects in more detail. Use of herbal products and potential interactions in patients with cardiovascular diseases. Saw palmetto might make your risk of bleeding higher if you also take a blood thinner, such as: It's not suggested to take St. John's wort if you take blood thinners. What should I know regarding pregnancy, nursing and administering Isosorbide Mononitrate to children or the elderly? A total of 195 drugs are known to interact with isosorbide mononitrate: A total of 330 drugs are known to interact with aspirin: A total of 239 drugs are known to interact with nitroglycerin: No known alcohol/food interactions. This activity describes the indications, action, and contraindications for isosorbide as a valuable agent in treating angina pectoris due to coronary artery disease, heart failure with reduced . Truven Health and GoodRx make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Older adults may be more sensitive to the side effects of this medication, especially dizziness and lightheadedness, which could increase the risk of falls. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). To avoid this, if you are taking more than one dose a day, your doses may not be prescribed at equal intervals throughout the day. Tachjian A, et al. Isosorbide dinitrate dose 30-120 mg daily in divided doses. http://www.upandaway.org. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. Call your doctor for medical advice about side effects. Nitrates (eg, isosorbide dinitrate, isosorbide mononitrate, nitroglycerin). It can cause your blood pressure to become dangerously low. What special dietary instructions should I follow? This medicine is a white, round, scored, tablet imprinted with "KU 107" and "20". This product is available in the following dosage forms: There is a problem with Modified-release nitrate preparations: use a once-daily dose to maintain a nitrate-low period and thus minimize tolerance. These headaches may be a sign that the medication is working as it should. This should pass after a few days. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). 1994 Jan;15(1):108-13. doi: 10.1093/oxfordjournals.eurheartj.a060361. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Background: Nitrates, although important for the management of angina pectoris, cause significant headache in many patients. Do not take more or less of it or take it more often than prescribed by your doctor. ask your doctor about the safe use of alcoholic beverages while you are taking isosorbide. Before using this medication, tell your doctor or pharmacist your medical history, especially of: low blood pressure. This side-effect usually disappears after a few days, Do not drive and do not use tools or machines while affected, If either of these becomes troublesome, speak with your doctor. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Alternative cancer treatments: 11 options to consider. The body tends to develop a tolerance (decreased sensitivity) to ISMN when it is used continuously over 24 hours. This is called a medicine interaction. Isosorbide mononitrate is used to prevent chest pain (angina) in patients with a certain heart condition (coronary artery disease). Eur Heart J. Tolerance is more likely to happen if you don't take your dose at the same time every day. 88 ratings on Drugs.com. Unless there is a specific reason you need the brand, the generic medication will be a better value. Higher dosages are associated with stomach irritation and https://naturalmedicines.therapeuticresearch.com. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Sildenafil ( Viagra ), tadalafil ( Cialis ), avanafil ( Stendra ),and vardenafil ( Levitra) increase the blood pressure lowering effects of isosorbide mononitrate and may cause excessive reductions in blood pressure. Do not stop taking isosorbide without talking to your doctor. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Side effects : headache, mild dizziness If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Do not stop taking it without consulting your doctor. The table below contains some of the most common ones associated with isosorbide mononitrate. If you notice any other effects, check with your healthcare professional.Call your doctor for medical advice about side effects. It is usually caused by narrowing of your coronary arteries due to a build-up of a fatty substance called atheroma. Although unlikely, when this medication is used for a long time, it may not work as well and may require different dosing. Contraindications: Isosorbide mononitrate should not be used in cases of acute myocardial infarction with low filling pressure, acute circulatory failure (shock, vascular collapse), or hypertrophic obstructive cardiomyopathy (HOCM), constrictive pericarditis, low cardiac filling pressures, aortic/mitral valve stenosis and diseases associated with a raised intra-cranial pressure e.g following a head trauma and including cerebral haemorrhage. Isosorbide mononitrate, sold under many brand names, is a medication used for heart-related chest pain ( angina ), heart failure and esophageal spasms. Call your doctor if you have any unusual problems while you are taking this medication. It works to relax your blood vessels. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program. Isosorbide mononitrate belongs to the group of medicines called nitrates. Duplication for commercial use must be authorized by ASHP. Isosorbide mononitrate Alternatives Compared Isosorbide mononitrate Aspirin Nitroglycerin Prescription only Prescribed for Angina, Heart Failure, Angina Pectoris Prophylaxis. Accessed Sept. 7, 2022. Is it safe to drive while on this medicine? Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Take isosorbide exactly as directed. Accessed Sept. 7, 2022. It works by . 2017; doi:10.1016/j.jacc.2016.11.078. Good at preventing chest pain caused by heart disease, Available as a generic version, making it less expensive, Long-acting version only needs to be taken once daily, Short-acting tablets have to be taken on a very specific schedule for the medication to work best. Take extra precautions to avoid falling during your treatment with isosorbide. If you notice other effects not listed above, contact your doctor or pharmacist. Take your next dose at the regular time. Your doctor will schedule your doses so that there is a period of time every day when you are not exposed to isosorbide. Nitroglycerin has an average rating of Take the container with you, even if it is empty. the unsubscribe link in the e-mail. Along with its needed effects, a medicine may cause some unwanted effects. https://naturalmedicines.therapeuticresearch.com. Laboratory and/or medical tests (such as blood pressure) should be performed periodically to monitor your progress or check for side effects. Isosorbide mononitrate (Monoket) may interact with certain medications or supplements. McGraw Hill; 2022. https://accessmedicine.mhmedical.com/search. Isosorbide mononitrate (Monoket) is available as a generic medication and may be significantly cheaper compared to the brand version. The extended-release tablet usually is taken once daily in the morning. Keep all medications away from children and pets. GoodRx works to make its website accessible to all, including those with disabilities. Aspirin relieves pain and inflammation and helps to thin the blood. Treatment and prognosis of heart failure with preserved ejection . Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Overview of herbal medicines and dietary supplements. To provide you with the most relevant and helpful information, and understand which Accessed Sept. 7, 2022. Longer-acting tablets and capsules are taken once daily in the morning. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. It is important that you follow the instructions your doctor gives to you about when to take your doses. from the best health experts in the business. If you experience any other symptoms which you think may be due to the medicine, please speak with your doctor or pharmacist for further advice. Your body can get used to isosorbide mononitrate (Monoket), and the same amount of medication might no longer work as well as it used to. The IR version can help treat and prevent angina. All rights reserved. URL of this page: https://medlineplus.gov/druginfo/meds/a682348.html. Lifestyle changes such as dietary changes, exercise, and not smoking may help this drug work better. It's usually not a problem for most people unless you drink alcohol or take other medications that can also lower your blood pressure. Erectile dysfunction medications (e.g., sildenafil (Viagra), vardenafil (Levitra), tadalafil (Cialis)) cannot be taken while you're taking isosorbide mononitrate (Monoket). In case of overdose, call the poison control helpline at 1-800-222-1222. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. This information is aggregated and used to produce personalized reports that patients can reference. American Society of Health-System Pharmacists, Inc. Disclaimer, U.S. Department of Health and Human Services. Never take extra doses or stop taking it suddenly unless your provider tells you to do so. I would rather take the chance of a heart attack than have no quality of life. Isosorbide mononitrate is also sometimes prescribed alongside other medicines for people with heart failure. Some of these medicine interactions can be risky. An official website of the United States government. If you are having difficulty accessing this website, please call or email us at (855) 268-2822 or ada@goodrx.com so that we can provide you with the services you require through alternative means. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. These products are provided 'AS IS' and 'as available' for use, without warranties of any kind, either express or implied. Don't drink alcohol while taking isosorbide mononitrate (Monoket). CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. This medication may interfere with certain laboratory tests (including cholesterol levels), possibly causing false test results. It is in the nitrate class of drugs. 1998 Oct;61(10):577-83. Usually avoid combinations; use it only under special circumstances. In the remainder of them there was a highly significant time effect: the overall numbers of headache attacks in the first period of active treatment versus the second were 2,380 vs 1,400 (P < 0.003). The .gov means its official. Avoid combinations; the risk of the interaction outweighs the benefit. Do not use medications containing isosorbide dinitrate while using isosorbide mononitrate. Isosorbide can only be used to prevent angina; it cannot be used to treat an episode of angina once it has begun. This branded product is no longer on the market. What conditions does Isosorbide Mononitrate treat? Profen and Metoclopramide drug interaction, Metoclopramide and Nitrostat drug interaction, Metoclopramide and Alfentanil drug interaction, Risperdal and Metoclopramide drug interaction. Keep this medication in the container it came in, tightly closed, and out of reach of children. The use of the Truven Health products is at your sole risk. Journals of the American College of Cardiology. This medication belongs to a class of drugs known as nitrates. isosorbide mononitrate (Rx) Brand and Other Names: Imdur, Monoket, more. View all This medicine is available only with your doctor's prescription. Ask your doctor before using aspirin together with alcohol. Properly discard this product when it is expired or no longer needed. 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