Created Date: 2/10/2020 8:51:41 PM . /Contents 4 0 R pH 6.0 to 8.0 . %PDF-1.4 <> The product would later go on to be commercialized under the brand name Avicel by FMC Corporation. Packaging: 34 x 50 kgs fiber drums. Molecular weight: Not Applicable 1.5. It should be noted that native cellulose itself is completely indigestible, and its hydrolysis during the production of microcrystalline cellulose does not alter its behaviour in the intestine. However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? Fiber supplements can lessen the absorption of some . It is, however, a good source of fibre. At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. cas:9032-51-3 msds CELLULOSE PAB. Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. EMCOCEL 90 M. 130. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. It works as a moisture sponge and permits the controlled growth of spheroids. X\o^ Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. Microcrystalline Cellulose E460 MSDS 1. /MediaBox [0 0 612 792] ). ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. l~5C (1962). Enter your [postal] code to see information about local products, representatives and retailers, along with special offers in your area. < gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. /Group << /S /Transparency /CS /DeviceRGB /I false /K false >> Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. Avicel Microcrystalline cellulose is manufactured in the United States of America by Dupont. <> X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? MATERIAL SAFETY DATA SHEET Version: 1.0 1. Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. Have an order or account question, find answers in our Online Support articles. PDF (2.77 mb) 2021 FMC Sustainability Report. ( pb7c8BHqCRX_eL +90w~ gk[YBkf9eDNJdNn q^16mi=4Sr0~{lZ>yvMqS'e,MqB?;Oy9s'$8asJgEh0SS>|J58ub^q c Dh)#t'kTfIZT1-_y"+wXj,qo!~ozc}ZemZ``$'vj{, Ga;]2iY*DIh~F3Z!.pkL:bHHBTbIcw9.Xo$4,?On4s=R,KLz /M|#PF(j%j oF2[5 ,rx)bd1$LM4Dc-d\@W D?A?L/7>s]-};Z if^+e3}AeQ# U%l3K?WW$iJ:tSS8M /&N2R3d2Nl2u]qg*WVkq2lhJZIiE++nKfq)sO~z(d| 7u4w!o}::#l}tEw'M}BEntaugq**t|KZUTe-1J+|. Alginates also function as actives in some anti-reflux products. Learn about FMC's industry leading goal of net-zero emissions by 2035. Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. B;vLZpHU%ChUyD+[ q86@on$^X_HuH;3` Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. Microcrystalline cellulose (C6H10O5)n is refined wood pulp. SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . Foam Booster/Stabilizer; Rheology Modifier; Stabilizer-Emulsion; Suspending Agent . If you are already a ChemPoint customer then sign up for access to our online ordering website. 1.3. In large quantities it provides dietary bulk and may lead to a laxative effect. };khd5x=fr . /Resources 2 0 R endobj Material Safety Data Sheet or SDS for Microcrystalline cellulose 9004-34-6 from chemicalbook for download or viewing in the browser. $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? Validity Area. It is widely used within the pharmaceutical, food, and cosmetic sectors as a formulation aid. Explore our commitment to environmental, social, and corporate governance and discover how we are making an impact. "l%I-*j|-)@ EtG[TQd%8,.fg4QqH'-dV ?3Z#GK# dGnF7x*3yY\VUwPhmyYT@f67Zcsmdi!%94K@:L# vJeU-kzRT-(YX/fKC lH5JWy}DgKRR"Fs Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * Although the breakup of cellulose to form colloidal microcrystalline cellulose has no impact on calorific content of the material, colloidal microcrystalline cellulose contain soluble components (hydrocolloids) that are introduced during processing, which add calories to the product. You have already flagged this document.Thank you, for helping us keep this platform clean.The editors will have a look at it as soon as possible. Avicel PH-200 microcrystalline cellulose NF, Ph. Product and Company Identification . 4 0 obj Avicel PC 611 (FMC Biopolymer) Supplied by. United Nations Sustainable Development Goals, Alginates Protanal, Manucol, Protacid and More, Barrier membrane, Controlled release hydrophilic matrix, Taste masking, Carrageenan Gelcarin, Viscarin and More, Controlled release hydrophilic matrix, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Rheology modifier, Rheology modifier/stabilizer, Binder, Controlled release hydrophilic matrix, Rheology modifier, Rheology modifier/stabilizer, Shell - hard capsule, Tablet coatings, Thin films, Topical, Capsules, Other, Solutions, Suspensions, Tablets, Controlled release hydrophilic matrix, Hot melt extrusion, Muco-adhesive, Osmotic pump, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Topical. Biologicals by FMC. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. 3 0 obj 102331. Your file is uploaded and ready to be published. Revision No. cas:9000-11-7 msds Carboxymethyl cellulose. Microcrystalline cellulose (MCC) for industrial purposes is usually obtained from wood pulp and purified cotton linters. : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. Find answers in our support articles. Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0 endstream endobj 524 0 obj 458 endobj 525 0 obj << /Filter /FlateDecode /Length 524 0 R >> stream The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. Hi, let us know if you have any questions as you visit our website. ChemicalBook. Protect them from sunshine or rain. Report Category. Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM @LRvdSbi#$yg+\0-U VE-2CZ*K&V.MiLeu86)23NI+6tkLSfmWuR.T\>;8]$ipHJ_)*P.FHyD R^PQ4EC l 4h+:6:]=3?B}Y#eAs(l)V6IOG,OM4'R3#^Op?gYZ; m#6@6O$ ;Ro|U$NSs*\neT &CcB7ysrg7;6Eax $R9+q,)}YK-0/SI0K}d WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. The table below shows the most common physicochemical parameters of this raw material. Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. Microcrystalline Cellulose. In extrusion-spheronisation, it is the excipient of choice. The figure below illustrates the structural organisation of cellulose within plants. Chemical Formula: (C6H10O5)n 1.4. >> They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. }o]X4]. Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. Superior Performance: Provides excellent water uptake and rapid swelling . Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . : CL-611NF Date Approved: 01/13/2010. iQuLyI4D@yq#u0dZt=0?QUz{K6by_C"vW~Nj$bo? Watch Now. SDS. Microcrystalline cellulose in certain fiber supplements may cause mild side effects ().These may include gas, bloating and increased stool production.. Eur., JP Product Specifications: Chemical and Physical: Loss on drying 2.0 - 5.0 %* Bulk density 0.29 - 0.36 g/cc Identification A, B Passes Degree of polymerization NMT 350 units pH 5.5 - 7.0* Conductivity NMT 75 S/cm FMC Corporation. More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. 4. Eur., JPE . LOT #: Available upon request. Apply today! >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[ However, if handling bulk powders, observance of appropriate safeguards is recommended. cas:9004-36-8 msds CELLULOSE ACETATE BUTYRATE. Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. G2W4de=u183KGH{ vQ#4:1\wc
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